The Cleveland Browns struggled to get the running game going and Brandon Weeden couldn't pickup the slack with the passing game.
The Bills came out strong with two quick scores, but stalled after the injury to C.J Spiller. They went back to the quick shotgun passing game to take a commanding lead and picked off Brandon Weeden to seal the victory.
The Browns now head to Baltimore on short week for Thursday night football staring 0-4 right in the face.
While the Bills get the New England Patriots at home with momentum on their side.
Bills 24 Browns 14