The 49ers, with a record of 4-2, have won three straight games. Their defense has been outstanding, and Frank Gore has led a strong ground attack on offense.
Colin Kaepernick started the season very well with a career high of 412 yards passing against the Packers. However, since that opening day win, Kaepernick has not come close to the same level of effectiveness.
Kaepernick had four straight games with less than 170 yards passing. He completed only 47 of his 93 pass attempts, barely a 50 percent rate. Kaepernick also threw four interceptions and only three touchdowns over that four-game stretch.
Kaepernick bounced back with a good game this past Sunday against the Arizona Cardinals. He completed 16 of his 29 attempts for 252 yards and two touchdowns. He did throw one bad interception at the goal line, costing the 49ers points.
Vernon Davis had a monster game for the 49ers against the Cardinals. He had eight catches for 180 yards and two touchdowns. Davis repeatedly torched the Arizona defense for big plays, but you can bet that the Titans will do everything they can to contain Davis.
In order for the 49ers to defeat the Titans, Kaepernick must find success with other receivers, as Davis will likely receive double coverage on most pass plays.
This could mean a big day for Anquan Boldin, but it could also spell trouble for the 49ers offense. The 49ers have had minimal production in the passing game from anyone other than Davis or Boldin.
The other receivers have not been able to get open consistently, which is a large reason why Kaepernick has struggled.
The 49ers have turned to the ground attack, and Frank Gore, along with the offensive line, has carried the offense. After a slow start in the first two games, Gore has 417 yards rushing in the last four games.
Kaepernick and the 49ers will have to be careful with the ball, as Tennessee has the second best turnover margin in the league at plus eight. In addition to six interceptions, the Titans have recovered seven fumbles.
Defensively, the Titans allow an average of only 19.2 points per game, which is eighth best in the league and one spot better than the 49ers.
The Titans allow 223.8 yards per game through the air, which is 10th best in the NFL. They have 18 sacks, which is seventh best in the league.
It will be up to the offensive line to protect Kaepernick and for him to use his mobility to stay out of trouble.
The Titans also allow 111.2 yards-per-game rushing, which is only 19th in the league. However, they are very adept at causing fumbles, which can thwart any drive.
Playing in Tennessee, this will not be an easy game for Kaepernick. He faces a hostile crowd and a team that will try to blanket both Davis and Boldin in the passing game.
The key will be the 49ers rushing attack, holding on to the football and for Kaepernick to find some other receivers for big plays.
The prediction for Kaepernick is 13 completions in 26 attempts, for 156 yards, one touchdown and one interception. That will not be enough to get the 49ers a win, unless they get good productivity from Frank Gore and Kendall Hunter.
Expect Kaepernick to have a mediocre game unless he can hit on some big plays like he did against the Cardinals. That task will be a lot tougher against the Titans
All stats courtesy of espn.go.com.