Tottenham have defeated Manchester United just once in 10 tries, and they are steep underdogs to do it Wednesday in English Premier League action.
Both teams have 34 points in Premier League play, and both trail Arsenal by eight points atop the league table.
Tottenham are coming off a 3-0 win over Stoke City, which was their first clean sheet since Nov. 3. They have a new head coach in Tim Sherwood, and Spurs are on a three-match unbeaten streak with two wins and one draw.
No shock at Old Trafford that oddsmakers have Man U as the big home betting favorite at -149 with Tottenham at +410 and a draw line of +263, according to the Man U-Tottenham matchup report at OddsShark.com.
Man U have been winning but are not really in top form. They ride a four-match winning streak and enjoyed two clean sheets in those games.
Earlier this season at Tottenham, Spurs and the Red Devils played to a 2-2 draw.
The Red Devils were definitely not in top form in their most recent 1-0 win over Norwich City, needing a second-half goal from substitute Danny Welbeck.
Wayne Rooney did not play in the Norwich match because of injury but should go in this one. Man U need him, as he leads the club in goals, while Robin van Persie, who ranks second in goals, is still out with an injury.
Rooney scored both of the goals in the 2-2 draw Dec. 1 against Tottenham.
Spurs do not have a win over one of the top teams this season with draws facing Man U, Chelsea and Everton and losses to Arsenal, Manchester City and Liverpool.
Roberto Soldado leads Spurs with five goals, and he scored in their most recent match.
The Red Devils have not looked sharp in the midfield, and that was evident in the Norwich match. Spurs must take advantage of that and create scoring opportunities from that area of the pitch.
Last season at Old Trafford, Tottenham beat Manchester United, 3-2.
Prediction: 3-1 Man U