1. Randy Moss vs. Buffalo Bills
It is our opinion that we're going to see an aerial show on Monday night in Tom Brady's comeback—and all we need to do is look back to 2007 to see how dangerous the Brady/Moss combo is. While he'll probably get Leodis McKelvin, a talented young corner to cover him, it won't matter. Look for over 100 yards and two TDs in a big-time fantasy effort.
2. Larry Fitzgerald vs. San Francisco 49ers
The Fitz show will be front and center when the Niners head to the desert on opening day. With San Francisco's defense incapable of pressuring Kurt Warner, the Arizona QB will have the necessary time to locate this year's top fantasy football wide receiver, and this should lead to a big afternoon. Expect 100 yards and at least one TD.
3. Calvin Johnson vs. New Orleans
The freakish Calvin Johnson will once again prove impossible for NFL defenses to cover. The Saints, who should actually be improved on that side of the ball under new DC Gregg Williams, will have little success stopping Johnson, even with Matthew Stafford getting the starting nod on Monday. With the expected deficit the Lions should be playing with, that'll make for a lot of passing opportunities.
4. Roddy White vs. Miami Dolphins
White's become a star receiver in this league, and he'll continue getting better playing with Matt Ryan. While Miami is very disciplined as a unit, White will prove too much for this secondary to handle and will torch whichever corner Miami tries to line up opposite him.
Josh Morgan vs. Arizona Cardinals
While he'll most likely line up against Dominique Rodgers-Cromartie, Morgan has an opportunity for a big game if he can carry over his late season rookie success into year two. The Niners could also be playing from behind, which will increase his opportunities for catches and yards.
Ted Ginn Jr. vs. Atlanta Falcons
There was a reason the Falcons went out and traded for CB Tye Hill last week; their secondary is suspect. Look for Chad Pennington to target Ginn on a few deep balls and for at least one of them to connect. Solid fantasy sleeper play.
Others with Favorable Matchups
Greg Jennings vs. Chicago Bears
Jennings entrenched himself as one of the best receivers in the league last year and was rewarded with a multi-year extension this offseason. With Aaron Rodgers now beginning to flourish, look for he and Jennings to pick up right where they left off and for Jennings to once again be Rodgers' deep threat. He'll score in this one.
Vincent Jackson vs. Oakland Raiders
The Chargers should have a fairly easy go of it in Oakland with success coming both on the ground and in the air. When they do take to the air, look for Philip Rivers to target his No. 1 outside weapon and for Jackson to torch the Raiders secondary, assuming CB Nnamdi Asomugha isn't playing or isn't fully healthy.
Terrell Owens vs. New England Patriots
Monday night will be a good opportunity to see if the moves New England made in the offseason have shored up its secondary. Either way, this will be one of the few games we see T.O. on in prime time, and we expect him to make his presence felt. Trent Edwards will be looking towards his new No. 1 early and often.