Having lost their first game of the season last week, Sydney FC may have opened a window for Melbourne Victory to come after them in the battle for the A-League's Premier's Plate.
After building an almighty lead on top of the A-League table, the difference between first and second could be just five points after this week should Sydney slip up again and Victory win their match.
Melbourne City have proved to be Sydney FC's bogey team over their last five encounters, having not lost to them since 2014. They head into Friday's much-anticipated clash with their confidence high and their momentum up after a 5-1 win over Wellington Phoenix last week as well as their FFA Cup win over the Sky Blues in November.
The oddsmakers have the home side as $2.70 (AUD) outsiders, according to AustralianGambling.com.au, despite City having lost just one of their past nine home matches, with Sydney as $2.45 favorites and the draw at $3.50.
The knock on City is that they haven't won back-to-back matches since the first two games of this season, while Sydney haven't lost two in a row since late last season.
Melbourne Victory will be in the unusual position of cheering their cross-town rivals so that they can close the gap to Sydney with a win over Adelaide United at the same venue on Saturday night.
Victory returned to form with a 3-0 win away to Central Coast Mariners last week, with Besart Berisha and James Troisi getting on the scoresheet. Berisha now has 16 goals and is on track to beat his best-ever A-League season haul of 21.
Victory have lost just one of their past 11 league matches against the Reds and go into this as $1.42 favorites with the draw at $4.40 and bottom of-the-table Adelaide at $7.
The fourth and fifth teams in the table, Brisbane Roar and Perth Glory, both have home games they will be confident of winning.
Brisbane, unbeaten in eight matches in all competitions, face Wellington Phoenix, who have gone five matches without success.
The Roar are $1.67 to win this one, having lost just once to the Phoenix in Brisbane in 14 previous encounters. Wellington are $4.60 with the draw priced at $3.85.
Perth take on a Western Sydney Wanderers side who will be pleased after that derby win over Sydney last week. The Glory are unbeaten in their past three and have lost just two matches at NIB Stadium in their past 16.
Western Sydney haven't won in the west in over three years and accordingly are $3 outsiders, with the Glory at $2.20 and the draw at $3.60.
The remaining game of the round is the F3 derby, where Newcastle Jets are $1.72 favorites against Central Coast ($4.20). The past five F3 derbies in Newcastle have been draws. It's $4 for that to happen again.