Week 13 includes a slate of three Thursday games for the Thanksgiving holiday. Check out where your fantasy players rank among the league's best this week.
Quarterbacks
| Rank | Name | Team | Opponent |
| 1 | Peyton Manning | IND | at CLE |
| 2 | Tony Romo | DAL | vs SEA |
| 3 | Philip Rivers | SD | vs ATL |
| 4 | Kurt Warner | ARI | at PHI |
| 5 | Chad Pennington | MIA | at STL |
| 6 | Drew Brees | NO | at TB |
| 7 | Matt Ryan | ATL | at SD |
| 8 | Brett Favre | NYJ | vs DEN |
| 9 | Tyler Thigpen | KC | at OAK |
| 10 | Jay Cutler | DEN | at NYJ |
| 11 | Ben Roethlisberger | PIT | at NE |
| 12 | Aaron Rodgers | GB | vs CAR |
| 13 | Matt Cassel | NE | vs PIT |
| 14 | Trent Edwards | BUF | vs SF |
| 15 | David Garrard | JAX | at HOU |
| 16 | Jeff Garcia | TB | vs NO |
| 17 | Donovan McNabb | PHI | vs ARI |
| 18 | Jake Delhomme | CAR | at GB |
| 19 | Eli Manning | NYG | at WAS |
| 20 | Joe Flacco | BAL | at CIN |
| 21 | Jason Campbell | WAS | vs NYG |
| 22 | Derek Anderson | CLE | vs IND |
| 23 | Kyle Orton | CHI | at MIN |
| 24 | Kerry Collins | TEN | at DET |
| 25 | Matt Hasselbeck | SEA | at DAL |
| 26 | Ryan Fitzpatrick | CIN | vs BAL |
| 27 | Gus Frerotte | MIN | vs CHI |
| 28 | Daunte Culpepper | DET | vs TEN |
| 29 | Sage Rosenfels | HOU | vs JAX |
| 30 | Marc Bulger | STL | vs MIA |
| 31 | Shaun Hill | SF | at BUF |
| 32 | JaMarcus Russell | OAK | vs KC |
Running Backs
| Rank | Name | Team | Opponent |
| 1 | Ronnie Brown | MIA | at STL |
| 2 | Adrian Peterson | MIN | vs CHI |
| 3 | Marion Barber | DAL | vs SEA |
| 4 | DeAngelo Williams | CAR | at GB |
| 5 | Thomas Jones | NYJ | vs DEN |
| 6 | Michael Turner | ATL | at SD |
| 7 | Maurice Jones-Drew | JAX | at HOU |
| 8 | Warrick Dunn | TB | vs NO |
| 9 | LaDainian Tomlinson | SD | vs ATL |
| 10 | Frank Gore | SF | at BUF |
| 11 | Joseph Addai | IND | at CLE |
| 12 | Clinton Portis | WAS | vs NYG |