With the first and third teams on the NRL ladder having the week off, Cronulla, Brisbane and Manly are all looking to strengthen their positions in the top four as we head into the post-Origin period.
Cronulla travel to Gold Coast on Saturday night to take on the Titans, hoping to stay clear in second place and maintain the pressure on top-placed Melbourne.
The Sharks had five players involved in Origin 3, and exactly how many of those players return three days later will play a large part in determining the market for the match against the Titans.
As it stands, Cronulla are $1.60 AUD favourites, according to AustralianGambling.com.au, with the Titans, who knocked off the Dragons in their last match and must continue winning if they are to have any hope of making the finals, at $2.38.
Fourth-placed Manly had their five-match winning streak snapped when they were beaten by Penrith last week but can get things back on track when they face the Wests Tigers on Sunday afternoon at Brookvale.
The Sea Eagles are the shortest-priced favourite of the round at $1.17, with the Tigers on $5.25, with a huge line of 15.5 in their favour. Interestingly, the past six matches between these two have all featured a margin of at least 10 points, but they haven't met since Round 2 last year.
The Tigers had lost seven straight before beating the Knights last time out, but this looms as a much tougher task having not won at Brookvale in 14 years.
The Brisbane Broncos, who are always heavily impacted by Origin and have gone 2-3 over the Origin period this year, travel to Newcastle to face the Knights on Saturday evening.
Again, this market will be impacted by how many of the Broncos' best players back up from Wednesday, but they are listed at $1.30 on the betting lines with the Knights, who are on a six-match losing streak, at $3.60. The Broncos have won five straight against the Knights and haven't lost in Newcastle since 2010.
Round 19 begins in Auckland on Friday night with the New Zealand Warriors and the Penrith Panthers desperate to keep in touch with the top eight.
Both are four points out of the finals fight, with Friday's match somewhat of an early elimination matchup. The Panthers may have beaten the Sea Eagles last week, but they go into this one as $2.20 underdogs having lost their past two at Mt Smart Stadium.
The Warriors have won their past five at home and go into this one as $1.68 favourites.
Canberra Raiders are two points further back in 11th and face a must-win match against St George Illawarra at GIO Stadium later on Friday night.
The Dragons look like the most vulnerable team in the eight having lost six of their past nine and are $2.58 outsiders as they travel to the national capital, where they haven't played in two-and-a-half years.
So far the Raiders have been inconsistent but can keep their season alive with a win here. They are $1.52.
The sixth-placed North Queensland Cowboys could also be suspect to a late-season slump without Johnathan Thurston, but they have been battling away well recently, winning four of their five games over the Origin period.
South Sydney host them in Cairns on Sunday, a match which should be a virtual home game for the Cowboys, who are rightly $1.68 favourites.
South Sydney couldn't get past a half-strength Sydney Roosters team here and are unlikely to be able to knock off the Cowboys. The Rabbitohs are $2.20.