Justin Kluivert, Matthijs de Ligt, Frenkie de Jong and Donny van de Beek are reportedly being watched by Barca's recruitment team, continuing a longstanding tradition of players leaving the Dutch club's elite academy for the Camp Nou.
The two teams have enjoyed a close relationship ever since Johan Cruyff moved to Barcelona in the 1970s, with a subsequent spell as manager of both sides cementing a link that was renewed down the years by Louis van Gaal. It is because of Cruyff that the two broadly share a playing style and approach to academy production.
And the relationship could continue as Barca aim to update an ageing squad. Andres Iniesta, Lionel Messi, Luis Suarez and Gerard Pique are all 30 or over, highlighting the urgency with which the club must recruit the next generation of talent. It is only natural they should start at Ajax.
Kluivert, son of former Barcelona and Ajax player Patrick, is highly rated in his home country and is reportedly also of interest to Manchester United, who considered signing the striker in January, per Duncan Castles for Yahoo Sport. The 18-year-old has featured in 22 Eredivisie games so far this season, scoring six goals.
All four of the players have been regulars in the Ajax team this season. De Ligt, 18, and Van de Beek, 20, have both started 25 of a possible 26 league games, while De Jong, 20, has started 16 times.
Ajax are 10 points behind leaders PSV Eindhoven and haven't lifted the title since 2013-14, reflecting a regeneration project that is still in the works. Fourteen of the 25 Ajax players to have played for the club in 2017-18 are 21 or under.
Barcelona, meanwhile, are top of La Liga by eight points, making this the ideal time to begin searching for the next generation of talent.