According to A.J. Perez of USA Today, NFL spokesperson Brian McCarthy released a statement, saying: "We are looking into the matter. A question such as that is completely inappropriate and wholly contrary to league workplace policies."
Guice mentioned the question in an interview for SiriusXM NFL's Late Hits (h/t Perez and Heather Tucker) on Wednesday:
"It was pretty crazy. Some people are really trying to get in your head and test your reaction. ... I go in one room, and a team will ask me do I like men, just to see my reaction. I go in another room, they'll try to bring up one of my family members or something and tell me, 'Hey, I heard your mom sells herself. How do you feel about that?'"
Still, Guice called the combine a "great experience."
Guice's situation is similar to one that involved current New York Giants cornerback Eli Apple at the 2016 combine.
Per ESPN.com's Vaughn McClure, Atlanta Falcons assistant coach Marquand Manuel asked Apple if he liked men. Manuel later apologized, and the NFL said it would look into the incident.
Guice is considered one of the top running back prospects in the 2018 draft class after rushing for 1,251 yards and 11 touchdowns at LSU last season.
In his latest mock draft, Bleacher Report's Matt Miller had the New York Giants selecting Guice in the second round with the No. 34 overall pick.